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Article

Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

Gastroenterology - 1 Aug 1994

Brentnall T A, Crispin D A, Rabinovitch P S, Haggitt R C, Rubin C E, Stevens A C, Burmer G C

Abstract excerpt

BACKGROUND/AIMS: In long-term extensive ulcerative colitis, aneuploidy occurs earlier and loss of heterozygosity for p53 (p53 LOH) later during histological progression towards carcinoma. This study determined the time of onset of p53 mutation in this progression. METHODS: We developed a rapid, sensitive screening assay for p53 mutations at codon 248. The geographic distribution of this p53 mutation was mapped in...

Topics

Aneuploidy
Base Sequence
Codon
Colitis, Ulcerative
Colonic Neoplasms
DNA Mutational Analysis
Flow Cytometry
Genes, p53
Heterozygote
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Source

Identifiers

PMID: 8039614
DOI: 10.1016/0016-5085(94)90161-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8039614-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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