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Article

Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

Gastroenterology - 1 Aug 1994

Brentnall T A, Crispin D A, Rabinovitch P S, Haggitt R C, Rubin C E, Stevens A C, Burmer G C

Abstract excerpt

BACKGROUND/AIMS: In long-term extensive ulcerative colitis, aneuploidy occurs earlier and loss of heterozygosity for p53 (p53 LOH) later during histological progression towards carcinoma. This study determined the time of onset of p53 mutation in this progression. METHODS: We developed a rapid, sensitive screening assay for p53 mutations at codon 248. The geographic distribution of this p53 mutation was mapped in...

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Identifiers

PMID: 8039614
DOI: 10.1016/0016-5085(94)90161-9

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