p53 mutations and DNA ploidy in colorectal adenocarcinomas.

doi:10.1155/1998/396371

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Article

p53 mutations and DNA ploidy in colorectal adenocarcinomas.

Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology - 1 Jan 1998

Campomenosi P, Assereto P, Bogliolo M, Fronza G, Abbondandolo A, Capasso A, Bellomo P F, Monaco R, Rapallo A, Sciutto A, Orecchia R, Geido E, Giaretti W

Abstract excerpt

The p53 tumour suppressor gene has an important role in the the maintenance of genome stability and its mutational inactivation may be at the origin of aneuploidy in cancer cells. The aim of this study was to determine whether p53 mutations were associated to DNA aneuploidy, as assessed by flow cytometry, in colorectal adenocarcinomas. Analysis of p53 mutations spectrum of the sorted nuclei was done by Denaturing...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Aneuploidy
Base Sequence
Colorectal Neoplasms
Female
Flow Cytometry
Genes, p53
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphatic Metastasis

Male

Metaplasia

Middle Aged

Molecular Sequence Data

Mutation

Ploidies

Source

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Identifiers

PMID: 9807634
DOI: 10.1155/1998/396371
PMCID: PMC4615187

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