Article
p53, Ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas.
Laboratory investigation; a journal of technical methods and pathology - 1 Jan 1996
Weyrer K, Feichtinger H, Haun M, Weiss G, Ofner D, Weger A R, Umlauft F, Grünewald K
Abstract excerpt
Ki-ras mutations and DNA aneuploidy are common findings in human pancreatic ductal adenocarcinomas. An altered p53 tumor-suppressor gene has been suggested to cooperate with activated Ki-ras in malignant cellular transformation and could enhance genomic instability. We have investigated a panel o...
Topics
- Adult
- Aged
- Base Sequence
- Carcinoma, Ductal, Breast
- DNA, Neoplasm
- Female
- Genes, Tumor Suppressor
- Genes, p53
- Genes, ras
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pancreatic Neoplasms
- Ploidies
