Article
Association of p53 gene and protein alterations with metastases in colorectal cancer.
The American journal of surgical pathology - 1 Apr 1995
Bertorelle R, Esposito G, Del Mistro A, Belluco C, Nitti D, Lise M, Chieco-Bianchi L
Abstract excerpt
Using monoclonal antibody PAb 1801, p53 protein was detected in the neoplastic cells of 39 (46.9%) of 83 colorectal carcinomas studied. Patients with p53+ tumors showed a higher incidence of lymph node and liver metastases (p = 0.035); in patients whose tumors were located in the rectosigmoid, p5...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Colorectal Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Heterozygote
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational