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Article

Genetic diversity at the p53 locus between primary human colorectal adenocarcinomas and their lymph-node metastases.

International journal of cancer - 17 Mar 1997

Zhang J S, Caplin S, Bosman F T, Benhattar J

Abstract excerpt

In both the primary tumor and associated lymph-node metastases of 40 cases of Dukes' C colorectal adenocarcinomas, exons 5 to 9 of the p53 tumor-suppressor gene were examined by PCR amplification and single-strand-conformation-polymorphism(SSCP) analysis. Mobility shifts indicating p53 mutations, which were confirmed by direct sequencing, were identified in 14 primary cancers (35%) and in 19 of the 40 lymph-node...

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Identifiers

PMID: 9096648
DOI: 10.1002/(sici)1097-0215(19970317)70:6<674::aid-ijc8>3.0.co;2-s

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Source receipt: pubmed, retrieved 7 Sept 2026.

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