Article
Genetic diversity at the p53 locus between primary human colorectal adenocarcinomas and their lymph-node metastases.
International journal of cancer - 17 Mar 1997
Zhang J S, Caplin S, Bosman F T, Benhattar J
Abstract excerpt
In both the primary tumor and associated lymph-node metastases of 40 cases of Dukes' C colorectal adenocarcinomas, exons 5 to 9 of the p53 tumor-suppressor gene were examined by PCR amplification and single-strand-conformation-polymorphism(SSCP) analysis. Mobility shifts indicating p53 mutations,...
Topics
- Adenocarcinoma
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Female
- Genes, p53
- Humans
- Lymphatic Metastasis
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational