Article
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
Cancer research - 1 Dec 1990
Baker S J, Preisinger A C, Jessup J M, Paraskeva C, Markowitz S, Willson J K, Hamilton S, Vogelstein B
Abstract excerpt
Coordinate loss of one copy of the p53 gene and mutation of the remaining copy occur in colorectal carcinomas and in many other human malignancies. However, the prevalence of p53 gene mutations in carcinomas which maintain both parental copies of p53 has not previously been evaluated. Moreover, i...
Topics
- Adenoma
- Base Sequence
- Carcinoma
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Colorectal Neoplasms
- DNA Mutational Analysis
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction