Article
Clonal expansion of p53 mutant cells in leukemia progression in vitro.
Leukemia - 1 Jan 1994
Wada H, Asada M, Nakazawa S, Itoh H, Kobayashi Y, Inoue T, Fukumuro K, Chan L C, Sugita K, Hanada R
Abstract excerpt
Using the polymerase chain reaction followed by single-strand conformation polymorphism (PCR-SSCP) analysis and direct nucleotide sequence determination, the p53 gene was analyzed in six fresh leukemia samples from which cell lines with p53 mutations were established. Mutations of the p53 gene wh...
Topics
- Acute Disease
- Alleles
- Base Sequence
- Clone Cells
- DNA, Neoplasm
- Gene Amplification
- Gene Rearrangement
- Genes, Immunoglobulin
- Genes, p53
- Genome, Viral
- Herpesvirus 4, Human
- Humans
- Immunoglobulin Heavy Chains
- Leukemia
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sensitivity and Specificity