Article
Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis.
Cancer communications - 1 Jun 1991
Burmer G C, Crispin D A, Kolli V R, Haggitt R C, Kulander B G, Rubin C E, Rabinovitch P S
Abstract excerpt
Allelic deletions of the p53 gene previously were demonstrated by Southern hybridization to occur in high frequency in sporadic colon carcinomas and in a variety of other human tumors. We have examined the frequency of allelic loss of the p53 gene in carcinoma and dysplasia arising in patients with chronic ulcerative colitis who are heterozygous for the codon 72 polymorphism in exon 4 of the p53 gene. Cells...
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