Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis.

doi:10.3727/095535491820873254

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Article

Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis.

Cancer communications - 1 Jun 1991

Burmer G C, Crispin D A, Kolli V R, Haggitt R C, Kulander B G, Rubin C E, Rabinovitch P S

Abstract excerpt

Allelic deletions of the p53 gene previously were demonstrated by Southern hybridization to occur in high frequency in sporadic colon carcinomas and in a variety of other human tumors. We have examined the frequency of allelic loss of the p53 gene in carcinoma and dysplasia arising in patients with chronic ulcerative colitis who are heterozygous for the codon 72 polymorphism in exon 4 of the p53 gene. Cells...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Aneuploidy
Base Sequence
Carcinoma
Chromosome Deletion
Colitis, Ulcerative
Colonic Neoplasms
Exons
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p53

Genetic Carrier Screening

Humans

Male

Middle Aged

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 2049225
DOI: 10.3727/095535491820873254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2049225-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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