Article
Have p53 gene mutations and protein expression a different biological significance in colorectal cancer?
Journal of cellular physiology - 1 May 2002
Bazan Viviana, Migliavacca Manuela, Tubiolo Carla, Macaluso Marcella, Zanna Ines, Corsale Simona, Amato Antonella, Calò Valentina, Dardanoni Gabriella, Morello Vincenza, La Farina Mario, Albanese Ida, Tomasino Rosa Maria, Gebbia Nicola, Russo Antonio
Abstract excerpt
p53 alterations are considered the most common genetic events in many types of neoplasms, including colorectal carcinoma (CRC). These alterations include mutations of the gene and/or overexpression of the protein. The aim of our study was to assess whether in 160 patients undergoing resective surgery for primary operable CRC there was an association between p53 mutations and protein overexpression and between...
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