Role of the CDR1 region of the TCR beta chain in the binding to purified MHC-peptide complex.

doi:10.1093/intimm/6.10.1561

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Article

Role of the CDR1 region of the TCR beta chain in the binding to purified MHC-peptide complex.

International immunology - 1 Oct 1994

Lone Y C, Bellio M, Prochnicka-Chalufour A, Ojcius D M, Boissel N, Ottenhoff T H, Klausner R D, Abastado J P, Kourilsky P

Abstract excerpt

Single alanine substitutions were introduced into the CDR1 region of the beta chain of a Kd-restricted TCR. Mutants and wild-type TCR were attached to the zeta chain of the CD3 complex and expressed at the surface of a rat basophil cell line. Transfectants were tested for the binding of purified...

Topics

Animals
Basophils
Cell Line
H-2 Antigens
HLA-C Antigens
Models, Molecular
Mutation
Rats
Receptors, Antigen, T-Cell, alpha-beta
Recombinant Fusion Proteins
Structure-Activity Relationship
Transfection

Source

Open in PubMed

Identifiers

PMID: 7826946
DOI: 10.1093/intimm/6.10.1561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7826946-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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