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Article

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

Biochemistry - 1 Aug 2017

Merkle Patrick S, Irving Melita, Hongjian Song, Ferber Mathias, Jørgensen Thomas J D, Scholten Kirsten, Luescher Immanuel, Coukos George, Zoete Vincent, Cuendet Michel A, Michielin Olivier, Rand Kasper D

Abstract excerpt

T-Cell receptor (TCR)-mediated recognition of the peptide-bound major histocompatibility complex (pMHC) initiates an adaptive immune response against antigen-presenting target cells. The recognition events take place at the TCR-pMHC interface, and their effects on TCR conformation and dynamics are controversial. Here, we have measured the time-resolved hydrogen/deuterium exchange (HDX) of a soluble TCR in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Deuterium Exchange Measurement

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Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 28671821
DOI: 10.1021/acs.biochem.7b00385

Genes

HDX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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