Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmembrane polar residues of TCR beta chain are required for signal transduction.

International immunology - 1 Jul 1998

Fuller-Espie S, Hoffman Towler P, Wiest D L, Tietjen I, Spain L M

Abstract excerpt

Mutagenic analyses have identified structural motifs important for TCR-mediated signaling in the antigen-binding chains, CD3 and zeta subunits of the TCR complex. In this study, we altered selected residues in the transmembrane and extracellular constant regions of the TCR beta chain and expressed the mutants in a T hybridoma line bearing endogenous receptor. We measured cytokine production and apoptosis in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Mice
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutagenesis

Share to Mutation

Share to Sequence Homology, Amino Acid

Share to Signal Transduction

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 9701030
DOI: 10.1093/intimm/10.7.923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmembrane polar residues of TCR beta chain are required for signal transduction.PMID 9701030Read ↗

Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis.Semantic proximity Read ↗

TCRbeta transmembrane tyrosines are required for pre-TCR function.Semantic proximity Read ↗

Structural mutations of the T cell receptor zeta chain and its role in T cell activation.Semantic proximity Read ↗

Defects in signal transduction caused by a T cell receptor beta chain substitution.Semantic proximity Read ↗

Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.Semantic proximity Read ↗

Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain.Semantic proximity Read ↗

A novel strategy for the generation of T cell lines lacking expression of endogenous alpha- and/or beta-chain T cell receptor genes.Semantic proximity Read ↗

Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways.Semantic proximity Read ↗

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.Semantic proximity Read ↗

Genetic and mutational analysis of the T-cell antigen receptor.Semantic proximity Read ↗

Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.Semantic proximity Read ↗

Mutational analysis of conserved amino acids in the T cell receptor alpha-chain transmembrane region: a critical role of leucine 112 and phenylalanine 127 for assembly and surface expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.