Article
Transmembrane polar residues of TCR beta chain are required for signal transduction.
International immunology - 1 Jul 1998
Fuller-Espie S, Hoffman Towler P, Wiest D L, Tietjen I, Spain L M
Abstract excerpt
Mutagenic analyses have identified structural motifs important for TCR-mediated signaling in the antigen-binding chains, CD3 and zeta subunits of the TCR complex. In this study, we altered selected residues in the transmembrane and extracellular constant regions of the TCR beta chain and expresse...
Topics
- Amino Acid Sequence
- Animals
- Antibodies
- Antigens
- Apoptosis
- Humans
- Interleukin-2
- Mice
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Protein Structure, Tertiary
- Receptors, Antigen, T-Cell, alpha-beta