Article
Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1990
Geisler C, Schøller J, Wahi M A, Rubin B, Weiss A
Abstract excerpt
The TCR for Ag, on the majority of human T cells, is a disulfide-linked heterodimer composed of TCR-alpha and -beta chains noncovalently associated with the monomorphic CD3 complex composed of the CD3-gamma, -delta, -epsilon, and -zeta chains. The interactions involved in the assembly of the vari...
Topics
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- Cell Line
- Electrophoresis, Gel, Two-Dimensional
- Electrophoresis, Polyacrylamide Gel
- Flow Cytometry
- Humans
- Macromolecular Substances
- Mutation
- Receptors, Antigen, T-Cell
- Transfection