Article
Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.
The Journal of biological chemistry - 5 Mar 1990
Alcover A, Mariuzza R A, Ermonval M, Acuto O
Abstract excerpt
The T-cell antigen receptor (TcR) complex present on most T-cells is formed by a clone-specific disulfide-linked alpha/beta heterodimer noncovalently associated to the CD3 complex, the latter composed of five invariant polypeptides: gamma, delta, epsilon, zeta/zeta, or zeta/eta. The presence of c...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- CD3 Complex
- Cell Membrane
- Cloning, Molecular
- Genes
- Humans
- Lysine
- Macromolecular Substances
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Receptors, Antigen, T-Cell
- Restriction Mapping
- T-Lymphocytes
- Transfection