Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.

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Article

Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.

The Journal of biological chemistry - 15 Aug 1990

Blumberg R S, Alarcon B, Sancho J, McDermott F V, Lopez P, Breitmeyer J, Terhorst C

Abstract excerpt

The T cell receptor (TCR) for antigen consists, on the majority of peripheral lymphocytes, of an immunoglobulin-like, disulfide-linked heterodimeric glycoprotein: the alpha and beta chain. These proteins are noncovalently linked to at least four nonvariant proteins which comprise the CD3 complex: CD3 gamma, delta, epsilon, and zeta. Whereas the TCR alpha and beta proteins have positively charged residues in the...

Topics

Amino Acid Sequence
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Arginine
Base Sequence
CD3 Complex
Cell Line
Cell Membrane
Genetic Vectors
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lysine

Macromolecular Substances

Molecular Sequence Data

Mutation

Receptors, Antigen, T-Cell

T-Lymphocytes

Transfection

Source

Open in PubMed

Identifiers

PMID: 2143190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2143190-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.PMID 2143190Read ↗

Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.Semantic proximity Read ↗

Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain.Semantic proximity Read ↗

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