Article
Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing.
The Journal of experimental medicine - 1 Feb 1999
Manning T C, Parke E A, Teyton L, Kranz D M
Abstract excerpt
It has been proposed that the generally low affinities of T cell receptors (TCRs) for their peptide-major histocompatibility complex (pMHC) ligands (Kd approximately 10(-4) to 10(-7) M) are the result of biological selection rather than an intrinsic affinity limitation imposed by the TCR framewor...
Topics
- Alanine
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Gene Rearrangement, T-Lymphocyte
- Histocompatibility Antigens Class I
- Ligands
- Models, Immunological
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Peptides
- Protein Binding
- Receptors, Antigen
- Receptors, Antigen, T-Cell, alpha-beta