Article
Low affinity interaction of peptide-MHC complexes with T cell receptors.
Science (New York, N.Y.) - 20 Dec 1991
Matsui K, Boniface J J, Reay P A, Schild H, Fazekas de St Groth B, Davis M M
Abstract excerpt
The interaction of antigen-specific T cell receptors (TCRs) with their ligands, peptides bound to molecules of the major histocompatibility complex (MHC), is central to most immune responses, yet little is known about its chemical characteristics. The binding to T cells of a labeled monoclonal antibody to the TCR was inhibited by soluble class II MHC heterodimers complexed to different peptides. Inhibition was...
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