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Article

In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

Proceedings of the National Academy of Sciences of the United States of America - 9 May 2000

Holler P D, Holman P O, Shusta E V, O'Herrin S, Wittrup K D, Kranz D M

Abstract excerpt

T cell receptors (TCRs) exhibit genetic and structural diversity similar to antibodies, but they have binding affinities that are several orders of magnitude lower. It has been suggested that TCRs undergo selection in vivo to maintain lower affinities. Here, we show that there is not an inherent genetic or structural limitation on higher affinity. Higher-affinity TCR variants were generated in the absence of in...

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Identifiers

PMID: 10779548
DOI: 10.1073/pnas.080078297
PMCID: PMC25838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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