Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular modelling and endoplasmic reticulum retention of mutated TCR/CD3 complexes.

Scandinavian journal of immunology - 1 Jun 2001

Arnaud J, Erard M, Martin E, Llobera R, Gouaillard C, Constans J, Rubin B

Abstract excerpt

T cell receptor (TCR)/CD3 complex assembly takes place in the endoplasmic reticulum (ER). Normal TCR/CD3 complexes egress from the ER to the cis-Golgi, where the interaction with zeta2 homodimers occurs. This interaction leads to further uncontrolled transport of TCR/CD3/zeta molecules to the cell surface. The purpose of the present experiments was to determine firstly the basis for the impact of the Phe195/216...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brefeldin A
Share to CD3 Complex
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Jurkat Cells

Share to Protein Transport

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocytes

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 11422902
DOI: 10.1046/j.1365-3083.2001.00906.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular modelling and endoplasmic reticulum retention of mutated TCR/CD3 complexes.PMID 11422902Read ↗

Molecular mechanisms in the TCR (TCR alpha beta-CD3 delta epsilon, gamma epsilon) interaction with zeta 2 homodimers: clues from a 'phenotypic revertant' clone.Semantic proximity Read ↗

Association of the human CD3-zeta chain with the alpha beta-T cell receptor/CD3 complex. Clues from a T cell variant with a mutated T cell receptor-alpha chain.Semantic proximity Read ↗

Lysine 271 in the transmembrane domain of the T-cell antigen receptor beta chain is necessary for its assembly with the CD3 complex but not for alpha/beta dimerization.Semantic proximity Read ↗

Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.Semantic proximity Read ↗

[Study of the membrane expression of TcR/CD3 complex using somatic cell mutants].Semantic proximity Read ↗

Assembly of the TCR/CD3 complex: CD3ε/δ and CD3ε/γ dimers associate indistinctly with both TCRα and TCRβ chains. Evidence for a double TCR heterodimer modelSemantic proximity Read ↗

Structures of human γδ T cell receptor–CD3 complexSemantic proximity Read ↗

Assembly and function of the T cell antigen receptor. Requirement of either the lysine or arginine residues in the transmembrane region of the alpha chain.Semantic proximity Read ↗

Biochemical differences in the alphabeta T cell receptor.CD3 surface complex between CD8+ and CD4+ human mature T lymphocytes.Semantic proximity Read ↗

Structure of the T-cell antigen receptor: evidence for two CD3 epsilon subunits in the T-cell receptor-CD3 complex.Semantic proximity Read ↗

Conformational and biochemical differences in the TCR.CD3 complex of CD8(+) versus CD4(+) mature lymphocytes revealed in the absence of CD3gamma.Semantic proximity Read ↗

The CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.