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Article

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2007

Tian Shaomin, Maile Robert, Collins Edward J, Frelinger Jeffrey A

Abstract excerpt

Binding of peptide/MHC (pMHC) complexes by TCR initiates T cell activation. Despite long interest, the exact relationship between the biochemistry of TCR/pMHC interaction (particularly TCR affinity or ligand off-rate) and T cell responses remains unresolved, because the number of complexes examined in each independent system has been too small to draw a definitive conclusion. To test the current models of T cell...

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Share to Antigens, Viral
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17709510
DOI: 10.4049/jimmunol.179.5.2952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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