Article
CD3 delta establishes a functional link between the T cell receptor and CD8.
The Journal of biological chemistry - 31 Jan 2003
Doucey Marie-Agnès, Goffin Laurence, Naeher Dieter, Michielin Olivier, Baumgärtner Petra, Guillaume Philippe, Palmer Ed, Luescher Immanuel F
Abstract excerpt
T cells expressing T cell receptor (TCR) complexes that lack CD3 delta, either due to deletion of the CD3 delta gene, or by replacement of the connecting peptide of the TCR alpha chain, exhibit severely impaired positive selection and TCR-mediated activation of CD8 single-positive T cells. Because the same defects have been observed in mice expressing no CD8 beta or tailless CD8 beta, we examined whether CD3...
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