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Article

MHC-peptide ligand interactions establish a functional threshold for antigen-specific T cell recognition.

Human immunology - 1 Jul 1999

Reichstetter S, Kwok W W, Kochik S, Koelle D M, Beaty J S, Nepom G T

Abstract excerpt

Antigen-specific T cell recognition is dependent on the functional density of the TCR-ligand, which consists of specific MHC molecules and a specifically bound peptide. We have examined the influence of the affinity and concentration of exogenous peptide and the density of specific MHC molecules on the proliferation of a CD4+, DQA1*0501/DQB1*0201 (DQ2.1)-restricted, HSV-2-specific T cell clone. Using antigen...

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PMID: 10426278
DOI: 10.1016/s0198-8859(99)00038-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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