Article
Association of apolipoprotein E allele epsilon 4 with late-onset sporadic Alzheimer's disease.
American journal of medical genetics - 15 Sept 1994
Lucotte G, Visvikis S, Leininger-Müler B, David F, Berriche S, Réveilleau S, Couderc R, Babron M C, Aguillon D, Siest G
Abstract excerpt
Apolipoprotein E, type epsilon 4 allele (ApoE epsilon 4), is associated with late-onset sporadic Alzheimer's disease (AD) in French patients. The association is highly significant (0.45 AD versus 0.12 controls for epsilon 4 allele frequencies). These data support the involvement of ApoE epsilon 4 allele as a very important risk factor for the clinical expression of AD.
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Base Sequence
- DNA
- Genotype
- Humans
- Middle Aged
- Molecular Sequence Data
- Time Factors