Article
Apolipoprotein E: risk factor for Alzheimer disease.
American journal of human genetics - 1 Apr 1994
Tsai M S, Tangalos E G, Petersen R C, Smith G E, Schaid D J, Kokmen E, Ivnik R J, Thibodeau S N
Abstract excerpt
The apolipoprotein E gene (APOE) has three common alleles (epsilon 2, epsilon 3, and epsilon 4) that determine six genotypes in the general population. In this study, we examined 77 patients with late-onset Alzheimer disease (AD), along with an equal number of age- and sex-matched controls, for an association with the APOE-epsilon 4 allele. We show that the frequency of this allele among AD patients was...
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