Article
Apolipoprotein E: risk factor for Alzheimer disease.
American journal of human genetics - 1 Apr 1994
Tsai M S, Tangalos E G, Petersen R C, Smith G E, Schaid D J, Kokmen E, Ivnik R J, Thibodeau S N
Abstract excerpt
The apolipoprotein E gene (APOE) has three common alleles (epsilon 2, epsilon 3, and epsilon 4) that determine six genotypes in the general population. In this study, we examined 77 patients with late-onset Alzheimer disease (AD), along with an equal number of age- and sex-matched controls, for a...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Base Sequence
- Case-Control Studies
- Female
- Gene Frequency
- Genes
- Genetic Predisposition to Disease
- Heterozygote
- Homozygote
- Humans
- Logistic Models
- Male