Article
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
Neurology - 1 Aug 1993
Saunders A M, Strittmatter W J, Schmechel D, George-Hyslop P H, Pericak-Vance M A, Joo S H, Rosi B L, Gusella J F, Crapper-MacLachlan D R, Alberts M J
Abstract excerpt
Apolipoprotein E, type epsilon 4 allele (APOE epsilon 4), is associated with late-onset familial Alzheimer's disease (AD). There is high avidity and specific binding of amyloid beta-peptide with the protein ApoE. To test the hypothesis that late-onset familial AD may represent the clustering of s...
Topics
- Aged
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Female
- Gene Amplification
- Gene Frequency
- Humans
- Male
- Middle Aged
- Mutation