Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease.

doi:10.1038/ng0594-74

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Article

Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease.

Nature genetics - 1 May 1994

van Duijn C M, de Knijff P, Cruts M, Wehnert A, Havekes L M, Hofman A, Van Broeckhoven C

Abstract excerpt

Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The freque...

Topics

Adult
Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Family Health
Female
Gene Frequency
Genes, Dominant
Genotype
Humans
Male
Middle Aged
Netherlands
Odds Ratio
Polymerase Chain Reaction

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