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Article

Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer's disease.

Nature genetics - 1 May 1994

van Duijn C M, de Knijff P, Cruts M, Wehnert A, Havekes L M, Hofman A, Van Broeckhoven C

Abstract excerpt

Several studies have reported an association of the apolipoprotein E allele epsilon 4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele...

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Source

Identifiers

PMID: 8075646
DOI: 10.1038/ng0594-74

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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