Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type.

doi:10.1016/0304-3940(94)91081-2

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Article

Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type.

Neuroscience letters - 4 Jul 1994

Dai X Y, Nanko S, Hattori M, Fukuda R, Nagata K, Isse K, Ueki A, Kazamatsuri H

Abstract excerpt

Apolipoprotein E genotypes in 88 unrelated Japanese patients with NINCDS-ADRDA sporadic Alzheimer's disease (AD) were examined and compared with those of 93 healthy controls. Frequency of epsilon 4 allele was increased in patients with AD (31%) compared with controls (10%), as was reported previo...

Topics

Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Female
Genotype
Heterozygote
Homozygote
Humans
Japan
Male
Middle Aged
Reference Values

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