Apolipoprotein E epsilon 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers.

doi:10.1136/jmg.32.8.642

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Article

Apolipoprotein E epsilon 4 allele is a risk factor for familial and sporadic presenile Alzheimer's disease in both homozygote and heterozygote carriers.

Journal of medical genetics - 1 Aug 1995

St Clair D, Rennie M, Slorach E, Norrman J, Yates C, Carothers A

Abstract excerpt

While apoliprotein E (ApoE) epsilon 4 allele is now a well established risk factor for familial and sporadic senile Alzheimer's disease (AD), its role in the development of the rarer presenile or early onset type is controversial. Early studies showed no association; later ones found enrichment f...

Topics

Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoproteins E
Female
Gene Frequency
Genetic Carrier Screening
Homozygote
Humans
Male
Risk Factors

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