"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism.

doi:10.1016/0024-3205(95)00223-s

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Article

"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism.

Life sciences - 1 Jan 1995

Kroemer H K, Eichelbaum M

Abstract excerpt

In this review we highlight the information available on the genetic polymorphism of cytochrome P4502D6 expression in man. An absent function of this enzyme is observed in 7-10 percent of the Caucasian population which are referred to as Poor metabolizers as opposed to the remainder of the popula...

Topics

Animals
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Genetic Predisposition to Disease
Humans
Mixed Function Oxygenases
Neoplasms
Oxidation-Reduction
Pharmaceutical Preparations
Polymorphism, Genetic

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