Article
Pharmacogenetics: the molecular genetics of CYP2D6 dependent drug metabolism.
Annals of the Academy of Medicine, Singapore - 1 May 2000
Wong J Y, Seah E S, Lee E J
Abstract excerpt
INTRODUCTION: Genetic variation of drug metabolising enzymes has been recognised as one of the major causes of the inter-individual variability to drug response. The vast majority of drugs are degraded via a small number of metabolic pathways, mainly by microsomal P-450 enzymes localised in the liver and, to a minor extent, in the small intestine. Of these, CYP3A4 is the isozyme involved in the metabolism of most...
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