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Article

Cytochrome P450 Enzyme System: Genetic Polymorphisms and Impact on Clinical Pharmacology

1 Nov 1999

Abstract excerpt

The cytochrome P450 (CYP) enzyme system is involved in the metabolism and elimination of numerous widely used drugs. The capacity of this system varies from one person to another, leading to variable drug excretion rates and intersubject differences in the final serum drug concentrations. For this reason, therapeutic response and side-effects vary widely between patients treated with the same dose of drug. The...

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PMID: 10586308
DOI: 10.1177/000456329903600604

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