Article
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Clinical pharmacokinetics - 1 Jan 2009
Zhou Shu-Feng
Abstract excerpt
Part I of this article discussed the potential functional importance of genetic mutations and alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 polymorphisms on the clearance of and response to a series of cardiovascular drugs was addressed. Since CYP2D6 plays a major role in the metabolism of a large number of other drugs, Part II of the article highlights the impact of CYP2D6...
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