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Article

Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance.

Drug metabolism and pharmacokinetics - 1 Jan 2012

Teh Lay Kek, Bertilsson Leif

Abstract excerpt

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of...

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Identifiers

PMID: 22185816
DOI: 10.2133/dmpk.dmpk-11-rv-121

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