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Cytochrome P450: genotype to phenotype

14 Aug 2019

Abstract excerpt

The cytochromes P450 comprise a family of enzymes that are responsible for around three-quarters of all drug metabolism reactions that occur in human populations. Many isoforms of cytochrome P450 exist but most reactions are undertaken by CYP2C9, CYP2C19, CYP2D6 and CYP3A4. This brief review focusses on the first three isozymes which exhibit polymorphism of phenotype.If there is a wide variation in drug...

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PMID: 31411087
DOI: 10.1080/00498254.2019.1648911

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