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Article

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

Clinical pharmacokinetics - 1 Jan 2009

Zhou Shu-Feng

Abstract excerpt

Cytochrome P450 (CYP) 2D6 is one of the most investigated CYPs in relation to genetic polymorphism, but accounts for only a small percentage of all hepatic CYPs (approximately 2-4%). There is a large interindividual variation in the enzyme activity of CYP2D6. The enzyme is largely non-inducible and metabolizes approximately 25% of current drugs. Typical substrates for CYP2D6 are largely lipophilic bases and...

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PMID: 19817501
DOI: 10.2165/11318030-000000000-00000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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