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Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6.

Drug metabolism and drug interactions - 1 Jan 2013

Haertter Sebastian

Abstract excerpt

The cytochrome P450 2D6 (CYP2D6) belongs to a group of CYPs considered of utmost importance in the metabolism of xenobiotics. Despite being of only minor abundance in the liver, it is involved in the clearance of >25% of marketed drugs. Accordingly, CYP2D6 can be very efficiently inhibited by a couple of commonly used drugs such as some antidepressants, although induction by any drug has not been observed thus...

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PMID: 24088607
DOI: 10.1515/dmdi-2013-0032

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