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Article

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jan 2004

Zanger Ulrich M, Raimundo Sebastian, Eichelbaum Michel

Abstract excerpt

Of about one dozen human P450 s that catalyze biotransformations of xenobiotics, CYP2D6 is one of the more important ones based on the number of its drug substrates. It shows a very high degree of interindividual variability, which is primarily due to the extensive genetic polymorphism that influences expression and function. This so-called debrisoquine/sparteine oxidation polymorphism has been extensively...

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Identifiers

PMID: 14618296
DOI: 10.1007/s00210-003-0832-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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