Article
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.
Naunyn-Schmiedeberg's archives of pharmacology - 1 Jan 2004
Zanger Ulrich M, Raimundo Sebastian, Eichelbaum Michel
Abstract excerpt
Of about one dozen human P450 s that catalyze biotransformations of xenobiotics, CYP2D6 is one of the more important ones based on the number of its drug substrates. It shows a very high degree of interindividual variability, which is primarily due to the extensive genetic polymorphism that influences expression and function. This so-called debrisoquine/sparteine oxidation polymorphism has been extensively...
Topics
- Alleles
- Animals
- Biotransformation
- Cytochrome P-450 CYP2D6
- Humans
- Pharmaceutical Preparations
- Phenotype
- Polymorphism, Genetic
- Substrate Specificity