Article
Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.
Pharmacogenetics - 1 Jun 1997
Marez D, Legrand M, Sabbagh N, Lo Guidice J M, Spire C, Lafitte J J, Meyer U A, Broly F
Abstract excerpt
The polymorphic cytochrome P450 CYP2D6 is involved in the metabolism of various drugs of wide therapeutic use and is a presumed susceptibility factor for certain environmentally-induced diseases. Our aim was to define the mutations and alleles of the CYP2D6 gene and to evaluate their frequencies in the European population. Using polymerase chain reaction-single strand conformation polymorphism analysis, 672...
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