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Article

How and why to screen for CYP2D6 interindividual variability in patients under pharmacological treatments.

Current drug metabolism - 1 Mar 2010

De Gregori Manuela, Allegri Massimo, De Gregori Simona, Garbin Giulia, Tinelli Carmine, Regazzi Mario, Govoni Stefano, Ranzani Guglielmina Nadia

Abstract excerpt

Cytochromes P450 are members of a superfamily of hemoproteins that catalyze a variety of oxidative reactions in the metabolism of endogenous and exogenous hydrophobic substrates. Fifty-eight cytochrome P450 (CYP) isoenzymes belonging to 18 families have been identified in human cells; the corresponding genes are highly polymorphic, and genetic variability underlies interindividual differences in drug response....

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Source

Identifiers

PMID: 21171195
DOI: 10.2174/138920010791196274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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