Article
Suppression of signal sequence defects and azide resistance in Escherichia coli commonly result from the same mutations in secA.
Journal of bacteriology - 1 Jun 1995
Huie J L, Silhavy T J
Abstract excerpt
The SecA protein of Escherichia coli is required for protein translocation from the cytoplasm. The complexity of SecA function is reflected by missense mutations in the secA gene that confer several different phenotypes: (i) conditional-lethal alleles cause a generalized block in protein secretio...
Topics
- Adenosine Triphosphatases
- Alleles
- Azides
- Bacterial Proteins
- Base Sequence
- Biological Transport
- Drug Resistance, Microbial
- Escherichia coli
- Escherichia coli Proteins
- Membrane Transport Proteins
- Molecular Sequence Data
- Mutation
- Protein Sorting Signals
- SEC Translocation Channels
- SecA Proteins
- Suppression, Genetic