Article
PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains.
The EMBO journal - 1 Sept 1993
Osborne R S, Silhavy T J
Abstract excerpt
The SecY protein of Escherichia coli and its homologues in other organisms, are integral components of the cellular protein translocation machinery. Suppressor mutations that alter SecY (the prlA alleles) broaden the specificity of this machinery and allow secretion of precursor proteins with def...
Topics
- Alleles
- Amino Acid Sequence
- Bacterial Proteins
- DNA, Bacterial
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genes, Suppressor
- Models, Structural
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Plasmids
- Protein Conformation
- Protein Structure, Secondary
- SEC Translocation Channels
- Suppression, Genetic