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Article

PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains.

The EMBO journal - 1 Sept 1993

Osborne R S, Silhavy T J

Abstract excerpt

The SecY protein of Escherichia coli and its homologues in other organisms, are integral components of the cellular protein translocation machinery. Suppressor mutations that alter SecY (the prlA alleles) broaden the specificity of this machinery and allow secretion of precursor proteins with defective signal sequences. Twenty-five prlA alleles have been characterized. These suppressor mutations were found to...

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Identifiers

PMID: 8253067
DOI: 10.1002/j.1460-2075.1993.tb06013.x
PMCID: PMC413613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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