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Article

The variable subdomain of Escherichia coli SecA functions to regulate SecA ATPase activity and ADP release.

Journal of bacteriology - 1 May 2012

Das Sanchaita, Grady Lorry M, Michtavy Jennifer, Zhou Yayan, Cohan Frederick M, Hingorani Manju M, Oliver Donald B

Abstract excerpt

Bacterial SecA proteins can be categorized by the presence or absence of a variable subdomain (VAR) located within nucleotide-binding domain II of the SecA DEAD motor. Here we show that VAR is dispensable for SecA function, since the VAR deletion mutant secAΔ519-547 displayed a wild-type rate of cellular growth and protein export. Loss or gain of VAR is extremely rare in the history of bacterial evolution,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22389482
DOI: 10.1128/JB.00039-12
PMCID: PMC3347061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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