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Article

secG and temperature modulate expression of azide-resistant and signal sequence suppressor phenotypes of Escherichia coli secA mutants.

Journal of bacteriology - 1 Dec 1998

Ramamurthy V, Dapíc V, Oliver D

Abstract excerpt

SecA is a dynamic protein that undergoes ATP-dependent membrane cycling to drive protein translocation across the Escherichia coli inner membrane. To understand more about this process, azide-resistant (azi) and signal sequence suppressor (prlD) alleles of secA were studied. We found that azide resistance is cold sensitive because of a direct effect on protein export, suggesting that SecA-membrane interaction is...

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Identifiers

PMID: 9829959
DOI: 10.1128/JB.180.23.6419-6423.1998
PMCID: PMC107736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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secG and temperature modulate expression of azide-resistant and signal sequence suppressor phenotypes of Escherichia coli secA mutants.PMID 9829959Read ↗

Azide-resistant mutants of Escherichia coli alter the SecA protein, an azide-sensitive component of the protein export machinery.Semantic proximity Read ↗

Suppression of signal sequence defects and azide resistance in Escherichia coli commonly result from the same mutations in secA.Semantic proximity Read ↗

Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants.Semantic proximity Read ↗

The variable subdomain of Escherichia coli SecA functions to regulate SecA ATPase activity and ADP release.Semantic proximity Read ↗

Mutations that confer resistance to sodium azide affect the levels of two physiological isoforms of SecA in Escherichia coli.Semantic proximity Read ↗

Inactivation of protein translocation by cold-sensitive mutations in the yajC-secDF operon.Semantic proximity Read ↗

Characterization of cold-sensitive secY mutants of Escherichia coli.Semantic proximity Read ↗

Iron is a ligand of SecA-like metal-binding domains in vivo.Semantic proximity Read ↗

Translation arrest of SecM is essential for the basal and regulated expression of SecA.Semantic proximity Read ↗

SecD and SecF facilitate protein export in Escherichia coli.Semantic proximity Read ↗

Mutations conferring resistance to azide in Escherichia coli occur primarily in the secA gene.Semantic proximity Read ↗

Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli.Semantic proximity Read ↗

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