secG and temperature modulate expression of azide-resistant and signal sequence suppressor phenotypes of Escherichia coli secA mutants.

doi:10.1128/JB.180.23.6419-6423.1998

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Article

secG and temperature modulate expression of azide-resistant and signal sequence suppressor phenotypes of Escherichia coli secA mutants.

Journal of bacteriology - 1 Dec 1998

Ramamurthy V, Dapíc V, Oliver D

Abstract excerpt

SecA is a dynamic protein that undergoes ATP-dependent membrane cycling to drive protein translocation across the Escherichia coli inner membrane. To understand more about this process, azide-resistant (azi) and signal sequence suppressor (prlD) alleles of secA were studied. We found that azide r...

Topics

Adenosine Triphosphatases
Alleles
Azides
Bacterial Proteins
Biological Transport, Active
Cold Temperature
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Proteins
Gene Deletion
Genes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Membrane Transport Proteins

Mutation

Phenotype

Protein Conformation

Protein Sorting Signals

SEC Translocation Channels

Source

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Identifiers

PMID: 9829959
DOI: 10.1128/JB.180.23.6419-6423.1998
PMCID: PMC107736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9829959-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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secG and temperature modulate expression of azide-resistant and signal sequence suppressor phenotypes of Escherichia coli secA mutants.PMID 9829959Read ↗

Azide-resistant mutants of Escherichia coli alter the SecA protein, an azide-sensitive component of the protein export machinery.Semantic proximity Read ↗

Suppression of signal sequence defects and azide resistance in Escherichia coli commonly result from the same mutations in secA.Semantic proximity Read ↗

Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants.Semantic proximity Read ↗

The variable subdomain of Escherichia coli SecA functions to regulate SecA ATPase activity and ADP release.Semantic proximity Read ↗

Mutations that confer resistance to sodium azide affect the levels of two physiological isoforms of SecA in Escherichia coli.Semantic proximity Read ↗

Inactivation of protein translocation by cold-sensitive mutations in the yajC-secDF operon.Semantic proximity Read ↗

Characterization of cold-sensitive secY mutants of Escherichia coli.Semantic proximity Read ↗

Iron is a ligand of SecA-like metal-binding domains in vivo.Semantic proximity Read ↗

Translation arrest of SecM is essential for the basal and regulated expression of SecA.Semantic proximity Read ↗

SecD and SecF facilitate protein export in Escherichia coli.Semantic proximity Read ↗

Mutations conferring resistance to azide in Escherichia coli occur primarily in the secA gene.Semantic proximity Read ↗

Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli.Semantic proximity Read ↗

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