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Article

Translation arrest of SecM is essential for the basal and regulated expression of SecA.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2004

Murakami Akiko, Nakatogawa Hitoshi, Ito Koreaki

Abstract excerpt

The SecM protein of Escherichia coli contains an arrest sequence (F(150)XXXXWIXXXXGIRAGP(166)), which interacts with the ribosomal exit tunnel to halt translation elongation beyond Pro-166. This inhibition is reversed by active export of the nascent SecM chain. Here, we studied the physiological roles of SecM. Arrest-alleviating mutations in the arrest sequence reduced the expression of secA, a downstream gene on...

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Identifiers

PMID: 15302932
DOI: 10.1073/pnas.0404907101
PMCID: PMC514405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Translation arrest of SecM is essential for the basal and regulated expression of SecA.PMID 15302932Read ↗

Identification of a SecM segment required for export-coupled release from elongation arrest.Semantic proximity Read ↗

Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest.Semantic proximity Read ↗

Identification of a hyperactive variant of the SecM motif involved in ribosomal arrest.Semantic proximity Read ↗

The ribosomal exit tunnel functions as a discriminating gate.Semantic proximity Read ↗

Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulation.Semantic proximity Read ↗

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Semantic proximity Read ↗

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel.Semantic proximity Read ↗

Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.Semantic proximity Read ↗

Search for translation arrest peptides encoded upstream of genes for components of protein localization pathways.Semantic proximity Read ↗

Recycling of ribosomal complexes stalled at the step of elongation in Escherichia coli.Semantic proximity Read ↗

Characterization of cold-sensitive secY mutants of Escherichia coli.Semantic proximity Read ↗

The SsrA-SmpB ribosome rescue system is important for growth of Bacillus subtilis at low and high temperatures.Semantic proximity Read ↗

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