Article
Azide-resistant mutants of Escherichia coli alter the SecA protein, an azide-sensitive component of the protein export machinery.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1990
Oliver D B, Cabelli R J, Dolan K M, Jarosik G P
Abstract excerpt
Escherichia coli azi mutants, whose growth is resistant to millimolar concentrations of sodium azide, were among the earliest E. coli mutants isolated. Genetic complementation, mapping, and DNA sequence analysis now show that these mutations are alleles of the secA gene, which is essential for pr...
Topics
- Adenosine Triphosphatases
- Azides
- Bacterial Proteins
- Cell Membrane
- Chromosome Mapping
- Drug Resistance, Microbial
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genetic Complementation Test
- Membrane Transport Proteins
- Mutation
- SEC Translocation Channels
- SecA Proteins
- Sodium Azide