Article
Iron is a ligand of SecA-like metal-binding domains in vivo.
The Journal of biological chemistry - 22 May 2020
Cranford-Smith Tamar, Jamshad Mohammed, Jeeves Mark, Chandler Rachael A, Yule Jack, Robinson Ashley, Alam Farhana, Dunne Karl A, Aponte Angarita Edwin H, Alanazi Mashael, Carter Cailean, Henderson Ian R, Lovett Janet E, Winn Peter, Knowles Timothy, Huber Damon
Abstract excerpt
The ATPase SecA is an essential component of the bacterial Sec machinery, which transports proteins across the cytoplasmic membrane. Most SecA proteins contain a long C-terminal tail (CTT). In Escherichia coli, the CTT contains a structurally flexible linker domain and a small metal-binding domain (MBD). The MBD coordinates zinc via a conserved cysteine-containing motif and binds to SecB and ribosomes. In this...
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