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Article

A novel class of secA alleles that exert a signal-sequence-dependent effect on protein export in Escherichia coli.

Genetics - 1 Nov 2002

Khatib Karim, Belin Dominique

Abstract excerpt

The murine plasminogen activator inhibitor 2 (PAI2) signal sequence inefficiently promotes the export of E. coli alkaline phosphatase (AP). High-level expression of PAI2::AP chimeric proteins from the arabinose P(BAD) promoter is toxic and confers an Ara(S) phenotype. Most Ara(R) suppressors map to secA, as determined by sequencing 21 independent alleles. Mutations occur throughout the gene, including both...

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Source

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Identifiers

PMID: 12454053
DOI: 10.1093/genetics/162.3.1031
PMCID: PMC1462312

Genes

BAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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