Article
Allelic differences in the VHOx-1 gene explain the absence of a B cell clonal dominance in the primary response of C57BL/6 mice to phthalate.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 1995
Winter D B, Diamond M E, Abu-hadid M, Falkenberg S, Bankert R B
Abstract excerpt
A highly conserved Id (CRIXmp-1) associated with the murine (BALB/c) humoral immune response to the hapten phthalate (Xmp) is conspicuously absent in C57BL/6 mice. The absence of this Id in C57BL/6 mice is shown here to be due to the absence of the appropriate VH gene (VHOx-1) usage in the Xmp re...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Base Sequence
- Cell Communication
- Clone Cells
- Female
- Immunity
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Molecular Sequence Data
- Phthalic Acids
- Polymorphism, Genetic