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Article

Frequent occurrence of identical heavy and light chain Ig rearrangements

1 May 1997

Abstract excerpt

Single-cell PCR analyses of expressed Ig H and L chain sequences presented here show that certain rearrangements occur repeatedly and account for a major segment of the well-studied repertoire of B-1 cell autoantibodies that mediate the lysis of bromelain-treated mouse erythrocytes, i.e. antibodies reactive with phosphatldyicholine (PtC). We repeatedly isolated at least 10 different types of VH region...

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PMID: 9184914
DOI: 10.1093/intimm/9.5.689

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