Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies.

doi:10.1093/intimm/dxl003

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Article

Increased negative selection impairs neonatal B cell repertoire but does not directly lead to generation of disease-associated IgM auto-antibodies.

International immunology - 1 May 2006

Cassady-Cain Robin L, Kaushik Azad K

Abstract excerpt

To determine if increased negative B cell selection, due to lowered signaling threshold of responsiveness to a ligand as a result of SHP-1 deficiency, during ontogeny leads to the origin of disease-associated IgM auto-antibodies (AAbs), 47 V(H)J558+ VDJCmu rearrangements from SHP-1-deficient viable motheaten (me(v)/me(v)) and 24 J558+ VDJCmu rearrangements from normal me(v)/+ neonatal (<24 h post-birth) B cells...

Read the complete abstract on PubMed

Topics

Animals
Autoantibodies
B-Lymphocytes
Data Interpretation, Statistical
Gene Library
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Immunoglobulin M

Immunoglobulin mu-Chains

Mice

Mice, Inbred C57BL

Molecular Sequence Data

Phylogeny

Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 16569683
DOI: 10.1093/intimm/dxl003

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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